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Numerous have been practical as they bind selectively to possibly the CB1 or CB2 receptors, whereas THC has a similar affinity for both. Tritium-labelled cannabinoids like CP-55,940 were instrumental in identifying the cannabinoid receptors during the early nineteen nineties.[fifty three]

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Synthetic cannabinoids ended up made for cannabinoid investigate concentrating on tetrahydrocannabinol (THC), cannabinoid receptors, as well as endocannabinoids that activate them in the body. Synthetic cannabinoids ended up needed partly on account of lawful restrictions on normal cannabinoids, which make them tricky to acquire for investigation.

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